INHIBITION OF THE INCORPORATION OF CHLORIDE INTO THE TETRACYCLINE MOLECULE

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Abstract
A variety of compounds particularly 2,5 dimercapto-l,3,4-thiadiazole, 2 phenyl-5-mercapto-l,3,4 oxadiazole and 2-(2-furyl)-5-mercapto-oxadiazole caused a normally chlortetracycline producing strain of Streptomyces aureofaciens to produce predominantly tetracycline when added to the medium at levels of 5 to 50 ppm. The action of these chlorination inhibitors is not reversed by excessive chloride but can be reversed by the addition of excess Cu to the medium.