The vitamin B1 sparing action of fat and protein. 4. The effect of carbohydrate in diets deficient in vitamin B1 upon the survival and vitamin B1 content of the rat

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Abstract
Rats consuming as little as 9% sucrose or glucose in their diets were not able to survive in the absence of vit. B1 as did those receiving no carbohydrate. They did, however, survive longer than those consuming diets with higher proportions of carbohydrate. The amt. of vit. B1 in the tissue of animals receiving no vit. B1 was unaffected by the presence or absence of carbohydrate in the diet, even though those consuming carbohydrate were moribund and the others were well. The results support the hypothesis that signs of deficiency are due to the disturbed metabolism of carbohydrate in the absence of vit. B1.