CD2+, CD3‐, CD56/NCAM+ malignant lymphoma with TCRβ gene rearrangement: A case report

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Abstract
A case of CD56/NCAM+ malignant lymphoma is reported. Only a rare malignant lymphoma cell showed azurophilic granules in the cytoplasm of Giesma‐stained preparations, while electron microscopic examination revealed occasional cytoplasmic granules with paracrystalline inclusions. The most common phenotype seen in NK lymphomas, CD2+, CD3‐, CD56+, CD16‐, CD57‐, was present in the case. Cases with this phenotype have been interpreted to represent either true NK lymphoma or T‐cell lymphoma with NK expression. Genotyping, where performed, has shown TCR germline configuration. Our case showed TCRβ rearrangement indicating that the above phenotype can be associated with a peripheral T‐cell lymphoma.