Blood Ketone Body Disappearance Rate in Diabetics and Normals after Rapid Infusion of DL‐3‐hydroxybutyrate

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Abstract
Ketone body tolerance was studied in 26 newly diagnosed diabetics and 9 normal control persons after rapid i.v. infusion of DL-3-hydroxybutyrate. In juvenile diabetics with high initial fasting concentrations of ketone bodies, disappearance rates of acetoacetate and total ketone bodies in blood were low before diabetic regulation. Insulin treatment normalized disappearance rates. In non-obese maturity onset diabetics, ketone body disappearance rates remained abnormally low after treatment with glibenclamide. In obese maturity onset diabetics, disappearance rates, being normal before diabetic regulation, decreased during phenformin treatment, the rate constants becoming significantly lower than in the normals. Decreased tissue uptake of ketone bodies seems to contribute to the increased ketone body level in blood in this group of diabetics. Disappearance rates were not correlated to preinfusion ketone body concentration. In the normals no change in serum insulin was observed following the infusion, while a significant decrease was seen in plasma glucose.