Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 2 (11) , 1195-1200
- https://doi.org/10.1093/carcin/2.11.1195
Abstract
An enzymatic activity present in rat liver extracts catalyzes the transfer of methyl groups from O6-methylguanine in DNA to protein. This activity was stimulated by treatment of rats with thioacelamide, carbon tetrachioride, 1,2-dimethylhydrazine, diethylnitrosamine, dimethylnitrosamine and by partial hepatectomy but not by treatment with N-methyl-N-nitrosourea or streptozotocin. These results suggest that an enhancement of this activity accompanies the in crease in cell division brought about by these agents and is not necessarily a specific response to the presence of alkylated bases in DNA.This publication has 19 references indexed in Scilit:
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