SPONTANEOUS HYPOGLYCAEMIA AND SARCOMA

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Abstract
A patient with a slow-growing fibrosarcoma of ovarian origin developed attacks of hypoglycemia. Estimations of plasma insulin-like activity and immunoassay of plasma insulin under a variety of conditions showed no evidence of abnormal insulin secretion. The responses to glucagon, tolbutamide, and L-leucine showed no definite abnormality. Possible mechanisms for the occurrence of the hypoglycemia are discussed.