Clinical Investigation of Disorders of Olfaction

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Abstract
The receptor cells in the olfactory neuroepithelium are regularly replaced and, when injured, regenerate from basal cells and reestablish their central connections. This process of reconstitution occurs throughout the life span after mechanical, chemical, and infectious injury. The history and physical findings in association with the quantification of the olfactory loss allow an etiologic diagnosis in many patients. Olfactory losses can be categorized as transport or sensorineural defects. Therapy for transport olfactory losses is frequently effective in restoring the sense of smell. Reasonable strategies for treatment of patients with sensorineural olfactory losses remain limited.