ANTI-GONADOTROPHIC ACTIVITIES OF QUINONES AND RELATED COMPOUNDS

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Abstract
Optimum conditions for determining the anti-PMS activity of 2,6-dimethylhydroquinone (DMHQ) were studied. Other agents among the quinones and from several classes of polyhydroxy compounds had varying inhibitory activity by this in vitro test, depending upon the individual chemical structure. Only DMHQ and hydroquinone, however, affected reproductive processes in in vitro test, depending upon the individual chemical structure. Only DMHQ and hydroquinone, however, affected reproductive processes in in vivo tests upon injection, as shown by rat estrus cycle changes. Neither of these were active when given orally. Upon continued parenteral administration rats became refractive to these 2 compounds and resumed cycling.