TIME COURSE OF FREE AND N4-ACETYLATED SULFAPYRIDINE CONCENTRATIONS IN PLASMA AND SALIVA OF MAN AFTER SULFASALAZINE (SALICYLAZOSULFAPYRIDINE) ADMINISTRATION - PRELIMINARY FINDINGS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (1) , 183-189
Abstract
The time course of free and N4-acetylated sulfapyridine (SP) concentrations in the saliva and whole plasma was determined in a healthy male volunteer after a single 2.0 g oral dose of salicylazosulfapyridine (SASP) as 4 500 mg commercial, uncoated tablets. The mean (.+-. SD) plasma:saliva concentration ratios for free and acetylated SP were 2.04 (.+-. 0.24) and 3.12 (.+-. 0.43), respectively, and, were independent of plasma concentration and saliva pH. The elimination half-lives of SP and N4-acetyl SP could be determined from either salivary or plasma concentration-time data. Measurement of saliva concentrations of free and acetylated SP may be a convenient, noninvasive method for monitoring indirectly the plasma concentrations of SP and acetyl SP in patients treated with SASP and for determining acetylator phenotype.

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