Ketoconazole: A Possible Direct Cytotoxic Effect on Prostate Carcinoma Cells
- 1 January 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 141 (1) , 190-191
- https://doi.org/10.1016/s0022-5347(17)40639-2
Abstract
Ketoconazole has been recently used in the treatment of advanced prostatic cancer and is believed to exert its effect by inhibition of androgen production. In order to determine whether ketoconazole exerts an additional direct cytotoxic effect on prostate cancer cells, we studied its effect on human hormone-independent prostate cancer cell lines (PC-3 and DU-145) in an in vitro clonogenic tumor assay. We showed that clinically achievable doses of ketoconazole caused greater than 90% suppression of tumor colony growth.This publication has 17 references indexed in Scilit:
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