Studies of a DNA marker (G8) genetically linked to Huntington disease in British families
- 1 August 1986
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 73 (4) , 333-339
- https://doi.org/10.1007/bf00279096
Abstract
Close genetic linkage has been shown between the DNA sequence G8 (locus D4S10) and 16 British families with Huntington disease using the HindIII, EcoR1, Nci1, and Pst1 polymorphisms detected by G8, and by combining all the polymorphisms to give a combined haplotype. Two recombinants have been detected in these families giving a maximum lod score of 17.60 at a Θ of 0.02. These results confirm the originally reported linkage between the loci and provide evidence against significant multilocus heterogeneity for Huntington disease.Keywords
This publication has 12 references indexed in Scilit:
- Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf–Hirschhorn syndromeNature, 1985
- Huntington's Disease: Two Families with Differing Clinical Features Show Linkage to the G8 ProbeScience, 1985
- Genetic prediction and family structure in Huntington's chorea.BMJ, 1985
- Report of the committee on the genetic constitution of chromosomes 3 and 4Cytogenetic and Genome Research, 1985
- Strategies for multilocus linkage analysis in humans.Proceedings of the National Academy of Sciences, 1984
- A polymorphic DNA marker genetically linked to Huntington's diseaseNature, 1983
- A life table for onset of Huntington's choreaAnnals of Human Genetics, 1981
- Huntington's Chorea in South Wales A genetic and epidemiological studyClinical Genetics, 1981
- Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.Proceedings of the National Academy of Sciences, 1977
- Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.1974