Positive‐ion fast‐atom bombardment tandem mass spectrometry of peptide nucleic acids
- 1 December 1994
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 8 (12) , 925-928
- https://doi.org/10.1002/rcm.1290081203
Abstract
The base sequence of synthetic peptide nucleic acids (PNAs), novel antisense agents, was analyzed by positive-ion fast-atom bombardment tandem mass spectrometry (FAB-MS/MS). Upon high-energy collisional activation decomposition, PNA oligomers provided apparent MS/MS product ions resulting from specific cleavage along the PNA backbone.Keywords
This publication has 8 references indexed in Scilit:
- Sequence specific inhibition of DNA restriction enzyme cleavage by PNANucleic Acids Research, 1993
- Single base pair mutation analysis by PNA directed PCR clampingNucleic Acids Research, 1993
- Antisense and Antigene Properties of Peptide Nucleic AcidsScience, 1992
- Recognition of guanine and adenine in DNA by cytosine and thymine containing peptide nucleic acids (PNA)Journal of the American Chemical Society, 1992
- Peptide nucleic acids (PNA). Oligonucleotide analogs with an achiral peptide backboneJournal of the American Chemical Society, 1992
- Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted PolyamideScience, 1991
- Letter to the editorsJournal of Mass Spectrometry, 1984
- Synthesis of benzyl and benzyloxycarbonyl base-blocked 2'-deoxyribonucleosidesThe Journal of Organic Chemistry, 1982