CANCEROSTATICS .4. ON THE SYNTHESIS OF SOME NOVEL 1-AZACARBAZOLE DERIVATIVES AS ANTI-NEOPLASTIC AGENTS
- 1 January 1981
- journal article
- research article
- Vol. 33 (1) , 121-127
Abstract
By condensation of 2-chloro-3-nitropyridine with some anilines, the corresponding 2-anilino-3-nitropyridines 1a.sbd.11 were obtained. Hydrogenation of these compounds and subsequent diazotization of the 2-anilino-3-aminopyridine derivatives 2a.sbd.21 gave triazoles 3a.sbd.31, which thermally decomposed in liquid paraffin to afford the required 6- and 8-substituted 1-azacarbazole derivatives 4a.sbd.e, i.sbd.l. Some of these compounds showed significant activity against transplanted mouse sarcoma 180. None of them were active against [murine] L 1210 and P 388 leukemias.This publication has 3 references indexed in Scilit:
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