ADRENOCORTICAL INFLUENCES ON DIPEPTIDASE ACTIVITY OF SURVIVING RAT DIAPHRAGM1

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Abstract
By the use of a procedure which permits quantitative measurement of the rate of cleavage of glycylglycine (dipeptidase activity) by surviving rat diaphragm it was observed that: (1) Dipeptidase activity was significantly lowered following adrenalectomy; (2) Cortisone administration to the rats increased the activity appreciably, but this stimulating effect was not demonstrable in vitro. (3) The increase in dipeptidase activity due to the cortisone administration persisted, even though dipeptidase activity is strongly activated by Co or inhibited by glutathione. Implications of these findings are discussed in relation to the nature of protein catabolic effect of corticosteroids.