Secretion and effect of hydrochlorothiazide in bile and pancreatic juice

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Abstract
The concentration of C14-hydrochlorothiazide was measured in blood, bile, pancreatic juice, and urine collected in suitably prepared dogs for 1 hr after intravenous injection of a dose (27.5 mg) producing consistent diuresis. No appreciable radioactivity appeared in the secretin-stimulated pancreatic juice, but amounts indicating drug concentrations up to 600 µg/ml were found in the bile, similar to levels in the urine. Blood levels were less than 5 µg/ml. Increase in bile flow by intravenous infusion of Bromsulphalein dye solution or by secretin injection did not alter the biliary secretion pattern of hydrochlorothiazide. Thus, drug secretion in bile appeared to be independent of water secretion. Serum, bile, and pancreatic juice were analyzed for rate of flow, specific gravity, pH, Na, K, Cl, and CO2 and bile for cholic acid. Biliary parameters were not altered. Pancreatic secretion showed an increase in volume and in K concentration. CO2 concentration and pH increased if control values of CO2 were less than 130 mEq/liter. Flow and K results could be explained by nonspecific effects also seen in other tissues.