In vitro transformation of hamster and human cells with the adeno 7-SV 40 hybrid virus.

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Abstract
The adeno 7-SV40 [simian virus 40] hybrid virus produced in vitro transformation of primary hamster kidney cells and diploid human skin fibroblasts. Both of these transformations resembled those caused by SV40 in almost all respects. Differences between SV40 and the hybrid transformation included a shorter latent period for transformation with the hybrid virus at comparable multiplicities of infection as well as absence of infectious virus from hybrid-transformed hamster cells. The transformation was inhibited by adeno 7 antiserum but not by SV40 antiserum. With both cell systems the virus-specific SV 40 neoantigen could be demonstrated in practically every transformed cell. The in vitro transformations confirm the oncogenic potential of the hybrid virus.