Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration
Open Access
- 20 January 2009
- journal article
- Published by Springer Nature in BMC Neuroscience
- Vol. 10 (1) , 6
- https://doi.org/10.1186/1471-2202-10-6
Abstract
Animal models of Parkinson's disease have been widely used for investigating the mechanisms of neurodegenerative process and for discovering alternative strategies for treating the disease. Following 10 injections with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 25 mg/kg) and probenecid (250 mg/kg) over 5 weeks in mice, we have established and characterized a chronic mouse model of Parkinson's disease (MPD), which displays severe long-term neurological and pathological defects resembling that of the human Parkinson's disease in the advanced stage. The behavioral manifestations in this chronic mouse model of Parkinson's syndrome remain uninvestigated. The health benefit of exercise in aging and in neurodegenerative disorders including the Parkinson's disease has been implicated; however, clinical and laboratory studies in this area are limited. In this research with the chronic MPD, we first conducted a series of behavioral tests and then investigated the impact of endurance exercise on the identified Parkinsonian behavioral deficits.Keywords
This publication has 48 references indexed in Scilit:
- A chronic mouse model of Parkinson's disease has a reduced gait pattern certaintyNeuroscience Letters, 2007
- Endurance exercise promotes cardiorespiratory rehabilitation without neurorestoration in the chronic mouse model of Parkinsonism with severe neurodegenerationNeuroscience, 2007
- Parallel information processing in the water maze: Evidence for independent memory systems involving dorsal striatum and hippocampusPublished by Elsevier ,2006
- 5‐HT2A and α1b‐adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulantsEuropean Journal of Neuroscience, 2004
- Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-Type Human α-SynucleinJournal of Neuroscience, 2004
- Multidisciplinary approaches for investigating the mechanisms of hippocampus-dependent memory: a focus on inbred mouse strainsNeuroscience & Biobehavioral Reviews, 2004
- Effects of probenecid on striatal dopamine depletion in acute and long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated micePublished by Elsevier ,2002
- Learning and Memory Functions of the Basal GangliaAnnual Review of Neuroscience, 2002
- Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: Further evidence for multiple memory systems.Behavioral Neuroscience, 1992
- Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog SynthesisScience, 1983