The chemical modification of Escherichia coli ribosomes with methyl p-nitrobenzenesulfonate. Evidence for the involvement of a histidine residue in the functioning of the ribosomal peptidyl transferase
- 1 December 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 58 (12) , 1345-1347
- https://doi.org/10.1139/o80-182
Abstract
Free 70S ribosomes and 70S ribosome-AUG-fMet-tRNA complexes were reacted, separately with methyl p-nitrobenzenesulfonate. This reagent inhibits the peptidyl transferase activity of 70S ribosome-AUG-fMet-tRNA but not of free 70S ribosomes. Methyl p-nitrobenzenesulfonate apparently reacts with a unique site which is a part of the ribosomal peptidyl transferase.This publication has 6 references indexed in Scilit:
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