Septic Shock and Corticosteroids

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Abstract
The use of a massive dose of a glucocorticoid in the patient with septic shock remains controversial. Some physicians believe strongly that corticosteroids favorably influence the outcome in a patient in whom septic shock is present or developing, whereas others regard the data in support of such therapy as insufficient in view of the potential risks. Although some controlled clinical studies have shown favorable effects of massive doses of corticosteroids on morbidity and mortality in septic shock, many have not.1 The Food and Drug Administration recently reviewed the indications for the use of corticosteroids in septic shock, focusing on the . . .