Pharmacokinetics of Intra-Arterial Chemotherapy

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Abstract
Since the advent in 1944 of the use of a war-gas product, nitrogen mustard, in clinical medicine for treatment of lymphomas, a wide range of chemical agents with tumoricidal properties have been developed. These agents are especially toxic to cells in the process of division, normal as well as neoplastic. Although a great deal of research has been done to discover agents more specifically selective in destroying neoplastic cells, present studies and management methods are most often designed to determine the drug combinations, timing and ways of administration which result in a maximal antineoplastic effect with minimal disturbance to normal tissues and cells.