Absorption, Deposition and Placental Transfer of Zinc65 in the Rat

Publisher Website
Google Scholar
Abstract
Zn65 given orally and intraperitoneally to pregnant rats crossed the placenta and deposited in the fetus, the amount transferred in 24-48 hours ranging from 1% of the Zn65 retained by the dam at 11 days gestation to 60% at 22 days; a sharp increase in permeability of the placenta to Zn was noted at 18 days. Following oral administration, only about 5% of the tracer dose of Zn65 was retained by the dam. Radiozinc concentration paralleled total zinc values in maternal tissues; the kidney, liver and pancreas contained the highest levels of activity. Zn65 given intraperitoneally to the dam post partum was transferred to the young via the mammary gland.