CHANGES IN ANTI-ENDOTOXIN-IGG ANTIBODY AND ENDOTOXAEMIA IN 3 CASES OF GRAM-NEGATIVE SEPTIC SHOCK

  • 1 October 1989
    • journal article
    • research article
    • Vol. 29  (2) , 93-106
Abstract
Circulating endotoxin levels and IgG antibodies to a range of Gram-negative bacterial lipopolysaccharides (LPS) (endotoxins) of different sizes and structures were measured daily in three cases of septic shock. There was an inverse relationship between endotoxin levels and cross-reactive antibodies to the core glycolipid (CGL) region of lipopolysaccharide. This suggests that antibody to LPS-CGL was initially consumed by a superabundance of endotoxin, and that a resurgence of intrinsic anti-LPS-CGL antibody levels may be associated with a reduction of circulating endotoxin. The implication of these findings for passive antibody therapy of septic shock are discussed.

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