Occurrence of Growth-Hormone Deficiency in Acromegaly as a Result of Pituitary Apoplexy

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Abstract
HEMORRHAGIC necrosis is a well documented complication of pituitary tumor, thought by some to occur more frequently in eosinophilic adenomas than in chromophobe adenomas,1 and occasionally related to radiotherapy.2 , 3 We have been able to find in the literature endocrinologic evaluations of four acromegalic patients who survived apparent pituitary apoplexy. Two of these patients were observed to have regression of acromegalic signs, associated with improvement of diabetes mellitus in one patient4 and with the development of hypopituitarism in the other.5 In two other acromegalic patients hypopituitarism6 and amelioration of diabetes mellitus7 were observed to develop respectively, but the subsequent course of . . .