INTRAHEPATIC OBSTRUCTIVE JAUNDICE FOLLOWING THE ADMINISTRATION OF 75 MG. OF CHLORPROMAZINE

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Abstract
Intrahepatic obstructive jaundice occurred in a 53-year-old woman, 2 weeks after she had ingested only 75 mg of chlorpromazine. The bilirubin, total serum cholesterol and the alkaline phosphatase were markedly elevated, and the cephalin flocculation test was negative. A biopsy of the liver revealed normal hepatic cells, infiltration of the portal areas by neutrophils, lymphocytes and few eosinophils, and bile thrombi in the small biliary radicles. The peripheral blood showed a transient eosinophilia. The relation between drug ingestion and the appearance of jaundice is suggestive of hyper-sensitivity, and the reaction depends upon the individual''s sensitivity to the drug rather than upon the total amount taken.