OBSTRUCTIVE-TYPE JAUNDICE DUE TO CHLORPROMAZINE (THORAZINE)

22 January 1955

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 157 (4) , 321-325
https://doi.org/10.1001/jama.1955.02950210017005

Abstract

Chlorpromazine (Thorazine) (10-[γ-dimethylaminopropyl]-2-chlorophenothiazine hydrochloride) has become an extremely popular and widely used drug in all fields of medicine and surgery. The remarkable antiemetic effect of the drug has been observed experimentally¹and clinically.²It is of great usefulness in controlling severe and otherwise intractable nausea and vomiting associated with disease, drugs, and radiation. It is particularly valuable in the control of nausea and vomiting, relief of pain, and alleviation of anxiety and apprehension in patients having terminal cancer. Chlorpromazine also appears to be a useful therapeutic agent in some mental and emotional disturbances.³ EFFECTS Pharmacologically the drug primarily has a depressant effect on the central nervous system and secondarily has a milder antispasmodic, antihistaminic, and adrenalytic activity. It potentiates the effects of certain other drugs, particularly hypnotics, sedatives, narcotics, and anesthetics. The lesser side-effects noted with chlorpromazine therapy include drowsiness, postural hypotension, tachycardia, dryness of the mouth,

Keywords

This publication has 2 references indexed in Scilit:

JAUNDICE DUE TO METHYL TESTOSTERONE THERAPY
Annals of Internal Medicine, 1953
NEW ANTIEMETIC DRUG
JAMA, 1953