Genetic Regulation of the Development of Glomerular Sclerotic Lesions in the BUF/Mna Rat
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 54 (4) , 334-337
- https://doi.org/10.1159/000185890
Abstract
BUF/Mna strain rats spontaneously develop renal glomerular sclerotic lesions (RSL) at a nearly 100% incidence, diagnosed by hyperalbuminuria ( > 500 mg/dl) and glomerular lesions morphologically resembling one type of human focal glomerular sclerosis (FGS). Genetic segregation of RSL development was studied by crossing the BUF/Mna strain with two other rat strains, WKY/NCrj and ACI/NMs, which were free of RSL. Two autosomal recessive genes in the BUF/Mna rats were found to determine the susceptibility to RSL in both combinations of crosses.Keywords
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