Immunofluorescence studies on Civatte bodies and dyskeratotic cells with anti-keratin antibody.

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Abstract
Civatte bodies and dyskeratotic cells were investigated in some skin disorders using indirect immunofluorescence techniques with anti-human keratin antibody. In the disorders with lichenoid tissue reaction such as lichen planus and discoid lupus erythematosus, Civatte bodies were observed in the lower epidermis and upper dermis and they reacted distinctly to the antikeratin antibody. In malignant skin tumors which show dyskeratotic cells in the epidermis, such as basal cell epithelium and Bowen''s disease, dyskeratotic cells reacted more clearly to the antibody than other keratinocytes. These observations present additional new evidence for the hypothesis that Civatte bodies are derived from tonofilaments of keratinocytes.