Gonorrhoea in men with homosexual contacts. Serogroups of isolated gonococcal strains related to antibiotic susceptibility, site of infection, and symptoms.

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Abstract
In 37 homosexual men the incidences of urethral, rectal and pharyngeal gonorrhea were 45.9%, 56.8% and 27%, respectively. Local symptoms were present in all men with urethral gonorrhea but in only 25% of those with pharyngeal or rectal gonorrhea or both. Infection at 2 sites was found in 29.7% of the patients. Forty-nine gonococcal isolates from the 37 patients were serogrouped by coagglutination into 1 of the serogroups WI, WII or WIII; their susceptibility to benzylpenicillin, ampicillin, cefuroxime, doxycycline and spectinomycin were tested. Only 1 gonococcal isolate from each patient was counted when 2 isolates belonged to the same serogroup and had the same antibiotic susceptibility. Thus, 15.4%, 76.0% and 7.7% of the gonococcal strains belonged to serogroups WI, WII and WIII, respectively. There was a significantly lower incidence of WI strains and a significantly higher incidence of WII strains among men with homosexual contacts than among other patients with gonorrhea from the same geographical region. Gonococcal strains of serogroup WI were significantly more resistant to all antibiotics tested, except to spectinomycin, than randomly chosen WI strains. Among WII and WIII strains the incidence of diminished susceptibility to all antibiotics tested was about the same.

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