Studies on the Protective Effect of Allogeneic Marrow Grafts in the Rat following Whole-body Irradiation at Different Dose-rates

Publisher Website
Google Scholar
Abstract
In rats exposed to large doses of whole-body radiation at 3 different dose-rates, transplantation of syngeneic and allogeneic marrow was used to determine the doses which suppress the immune response to a foreign graft. This was compared with the dose levels at which hemorrhagic death and intestinal death occurred. A dose of 800 r of X rays at 29 r/minute suppressed the immune response sufficiently to prevent hemorrhagic death in rats given allogeneic marrow. At a dose-rate of 1[center dot]4 r/minute and a dose of 1,600 r (gamma rays), the largest dose that could be given without causing intestinal failure, allogeneic marrow was rejected. When the dose-rate was reduced to 0[center dot]28 r/minute, after a total dose of 2,870 r neither suppression of the immune response nor intestinal failure occurred.