Sensitivity of Amplifier T Cells Involved in the Antibody Response to Type III Pneumococcal Polysaccharide to Anti-Lymphocyte Serum
Open Access
- 1 September 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 119 (3) , 1159-1162
- https://doi.org/10.4049/jimmunol.119.3.1159
Abstract
Amplifier T cells responsible for enhancement of the antibody response to type III pneumococcal polysaccharide have been shown to be resistant to the effects of antilymphocyte serum (ALS) given at the time of immunization, a treatment that eliminates suppressor T cell activity. The resistance of amplifier T cells to ALS can be attributed to the fact that their activity develops after that of suppressor T cells. ALS given 1 or 2 days after immunization does abrogate amplifier T cell activity, independent of the mode by which that activity is elicited. The data emphasize the importance of kinetic considerations in understanding the effects produced by immunologically active agents such as ALS.This publication has 3 references indexed in Scilit:
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