The genetic control of transferrins in humans

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Abstract
The methods used to demonstrate variations in the serum [beta]-globulins of normal individuals are described. The variable [beta]-globulins are identified as transferrins. Family studies (28 matings, 79 offspring) show that the transferrins are genetically controlled at a single locus, Tf, by at least three alleles, Tfb, Tfc and Tfd. Tfc is the common allele. Tfb occurs approximately 1 in 100 in Canadian whites. Tfd occurs approximately 1 in 25 in New York negroes and approximately 1 in 10 in Australian aborigines. Four of the 6 possible phenotypes have been observed: Tf BC, Tf CC, Tf CD and Tf DD. Independent segregation of the genes at the Tf locus and those at the ABO, MNS, P, Rh and Hp loci has been observed.