Drug Effects on the Metabolism of Endamoeba Histolytica; in Vitro and in Vivo Tests of Synergism
- 1 March 1953
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 2 (2) , 206-211
- https://doi.org/10.4269/ajtmh.1953.2.206
Abstract
Summary 1. An in vitro method is described for measuring the anaerobic metabolism of E. histolytica in terms of acid and CO2 formation, utilizing manometric technics. 2. The effects of several agents on the metabolic activity of amebas have been studied. Synergism was observed when drug combinations were tested in vitro, notably with fumagillin and terramycin and with fumagillin and thiocarbarsone (C.C. 914). 3. Four of five naturally infected macaques were cleared over a 12 week period when ¼ the smallest effective oral dose of fumagillin and terramycin (each 12.5 mgm./Kg.) were given together daily over ten days.Keywords
This publication has 4 references indexed in Scilit:
- In vitro and in vivo Studies of a New Antibiotic, Fumagillin, with Endamoeba histolytica.Experimental Biology and Medicine, 1951
- Antibiotics against Amebiasis in MacaquesThe American Journal of Tropical Medicine, 1950
- Indirect in Vitro Action of Antibiotics in Comparison with Activity of Accepted AmebacidesThe American Journal of Tropical Medicine, 1950
- A LIQUID MEDIUM COMPOSED OF DEHYDRATED INGREDIENTS FOR CULTURE OF ENDAMOEBA-HISTOLYTICA ASSOCIATED WITH A SINGLE BACTERIUM1950