Inheritance of Dexamethasone Hypertension and Glaucoma

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Abstract
The dexamethasone hypertensive response was studied in patients with glaucoma and in their families. The genetic nature of the response was validated in parent-offspring comparisons. It was shown that glaucoma does not represent a homogeneous single group with respect to the dexamethasone hypertensive response and that it could not be described exclusively by PHPH, instead it showed in addition PLPH and PLPL as well. Open-angle glaucoma with hypertension showed similar genotype distribution as that without hypertension; this distribution differed markedly from that of the normal eye and included a greater frequency of PH. Studies in the normal eye of patients with glaucoma secondary to contusion angle recession revealed a significantly greater frequency of PH and suggested that the development of this glaucoma was dependent upon the genotype of the individual with respect to PL,PH. A hypothesis was offered that open-angle glaucoma is a polygenetically determined disease and that one of the allele pairs involved is PL,PH. This was generalized to include the development of glaucoma secondary to contusion recession.

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