EXPRESSION OF CR2 (C3d RECEPTOR) ON THE CELL MEMBRANES OF ADULT T CELL LEUKEMIA
- 30 June 1988
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 79 (7) , 805-808
- https://doi.org/10.1111/j.1349-7006.1988.tb00039.x
Abstract
MT-2 cells, which produce human T-cell lymphotropic virus type I (HTLV-1), are known to have a complement receptor. We have established that the complement receptor is CR2 which binds C3d on immune complexes but not CR1. CR2 was also detected on ATL-3I cells but no complement receptor was detected on ATL-1K cells which lack ATL antigen (ATLA). Since CR2 is not detectable on normal T lymphocytes, the presence of CR2 on some ATL cells might suggest that ATL cells were derived from a particular minor lineage of T cells, or HTLV-I has a capacity to induce CR2, which has been demonstrated to be an .alpha.-type growth factor for B lymphocytes and to be a receptor for Epstein-Barr virus.Keywords
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