Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens.

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Abstract
Partial amino-acid sequence analyses of the amino terminus of rabbit C-reactive protein and a peptide isolated from human C-reactive protein after CNBr cleavage show an extensive sequence homology between these proteins. Computer analysis detected a distant but significant homology between rabbit C-reactive protein and the CH3 [H chain constant region 3] domain of human Ig[immunoglobulin]G. The data available for the amino-acid sequences of human and mouse histocompatibility antigens revealed a similarity between these proteins and C-reactive protein and, thus, Ig. C-reactive protein and Ig share, in addition to functional similarities, a common evolutionary origin with the major histocompatibility antigens.