The Effect of D.F.P. on the Acute Intestinal Radiation Syndrome in the Rat

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Abstract
The administration of diisopropyl fluorophosphonate DFP either before or up to 24 hours after abdominal irradiation reduced mortality after 1050 and 1334 r DFP had no effect on irradiation induced leukopenia nor on the later deaths ("bone-marrow death") that occur after whole body irradiation. The effect of DFP treatment on histological changes in the intestine was studied. DFP appears to have an anti-inflammatory action on radiation injury to the intestine. The mode of action of DFP is discussed and it is suggested that this drug might act by preventing the formation of vasoactive polypeptides (kallikrein and kinins).