Immunologic Response to Tetanus Toxoid Inoculation in Patients with Hepatic Cirrhosis

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Abstract
THERE is some evidence that certain forms of chronic liver disease may be initiated by antigen–antibody reactions within liver cells. A heterogenetic antibody that fixes complement with human liver and agglutinates sheep red cells has been demonstrated in the serum of some persons suffering from acute hepatitis.1 Conceivably, in such cases, the antibody could combine with antigen in situ in the liver cells and lead to further tissue damage after the infection had disappeared.2 , 3 Furthermore, a substance, presumably antibody, that fixes complement in the presence of human liver homogenate has been found in the serum of patients having acute viral . . .