The Utility of a Single-Point Dosing Protocol for Predicting Steady-State Lithium Levels
- 1 April 1986
- journal article
- research article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 148 (4) , 401-405
- https://doi.org/10.1192/bjp.148.4.401
Abstract
Two methods for predicting steady-state serum lithium level were compared prospectively in in-patients suffering from affective disorder. A single-point prospective administration model that required a single 24-hour serum lithium level, following a test dose produced statistically similar predictions of the observed steady-state lithium levels as did a model that required 12- and 36-hour levels. However, the latter two-point method produced significantly more accurate predictions from clinical interpretation. Although the two-point approach is preferable, the single-point method is clinically acceptable if its limitations of accuracy are taken into consideration.This publication has 12 references indexed in Scilit:
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