The Effects of Multiple and Single Administration of Dimethylnitrosamine to Hamsters

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Abstract
A single treatment with dimethylnitrosamine (DMN) in rats has been reported to induce kidney tumors, in some cases ethmoidal tumors and very few or no liver tumors. The administration of one or three doses of DMN to hamsters results in the induction of liver cell carcinomas and of a few cholangiomatous lesions, and no kidney tumors. Dose and time of administration of DMN play probably a major role in the different carcinogenic responses to DMN observed in rats and hamsters.