ON THE FUNCTIONS OF X-IRRADIATED “FEEDER” CELLS IN SUPPORTING GROWTH OF SINGLE MAMMALIAN CELLS
- 1 December 1956
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 42 (12) , 900-906
- https://doi.org/10.1073/pnas.42.12.900
Abstract
Model studies des-ignated to elucidate how a feeder layer of X-irradiated, non-reproducing cells can promote colonial growth of single mammalian cells in an otherwise incompetent medium reveal 2 ways in which feeder cells can function. They can relieve a specific nutritional deficiency of the medium, and they can neutralize the toxic action of specific cell anti- bodies. The use of feeder systems as tools for the study of various aspects of mammalian cell behavior is discussed.Keywords
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