A Missense Mutation in the Seven-transmembrane Domain of the Human Ca2+ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator
Open Access
- 1 July 2006
- journal article
- Published by Elsevier
- Vol. 281 (30) , 21558-21565
- https://doi.org/10.1074/jbc.m603682200
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- Human P2Y6 Receptor: Molecular Modeling Leads to the Rational Design of a Novel Agonist Based on a Unique Conformational PreferenceJournal of Medicinal Chemistry, 2005
- Genetic variation in G-protein-coupled receptors – consequences for G-protein-coupled receptors as drug targetsEmerging Therapeutic Targets, 2005
- Calcimimetics and calcilytics—fooling the calcium receptorThe Lancet, 2005
- Crystals of Native and Modified Bovine Rhodopsins and Their Heavy Atom DerivativesJournal of Molecular Biology, 2004
- Positive and Negative Allosteric Modulators of the Ca2+-sensing Receptor Interact within Overlapping but Not Identical Binding Sites in the Transmembrane DomainJournal of Biological Chemistry, 2004
- Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 ReceptorJournal of Biological Chemistry, 2003
- Identification of Acidic Residues in the Extracellular Loops of the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2+ and a Positive Allosteric ModulatorPublished by Elsevier ,2002
- Two Mutations in Extracellular Loop 2 of the Human GnRH Receptor Convert an Antagonist to an AgonistMolecular Endocrinology, 2002
- Crystal Structure of Rhodopsin: A G Protein-Coupled ReceptorScience, 2000
- Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroidNature, 1993