The guinea pig I region. II. Functional analysis.

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Abstract
This paper examines whether an association exists between specific Ia [immune response-associated] antigen genes and Ir genes which are encoded within the same haplotype. Functionally monospecific sera to the Ia antigens of the guinea pig MHC [major histocompatibility complex] were selective in their ability to inhibit antigen-specific T [thymus-derived] cell proliferation. It was possible to demonstrate an association between individual Ia specificities and specific Ir genes. The results of these studies in inbred animals were confirmed by examining the association of Ir genes and Ia antigens in the outbred guinea pig population. Antisera made against cross-reactive Ia antigens of strains lacking specific Ir genes would still inhibit immune responses of strains possessing the Ir gene, if the Ir gene was associated with that Ia antigen in the responder strain.

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