Serotonin receptors, VII. Activities of various pure gangliosides as the receptors.
- 1 May 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 53 (5) , 959-963
- https://doi.org/10.1073/pnas.53.5.959
Abstract
A series of gangllosides and related sphingolipids were assayed for serotonin [5-hydroxytryptamine] receptor activity by 2 different methods of bloassay. The most active compound was a new gnaglioside called new G. Very much less activity was found in 3 other known gangliosldes, but no activity was present in such common ganglio-sldes as G1, G4, and the Tay-Sachs'' ganglioside. The results indicated that the serotonin receptors are definite and specific chemical substances, possibly one or more gangllosides such as new G.This publication has 14 references indexed in Scilit:
- SEROTONIN RECEPTORS, IV. SPECIFIC DEFICIENCY OF RECEPTORS IN GALACTOSE POISONING AND ITS POSSIBLE RELATIONSHIP TO THE IDIOCY OF GALACTOSEMIAProceedings of the National Academy of Sciences, 1964
- [FURTHER GANGLIOSIDES FROM THE HUMAN BRAIN].1964
- Isolation and analysis of mono-, di-, and trisialogangliosidesBiochimica et Biophysica Acta, 1963
- The Fixation of Tetanus Toxin, Strychnine, Serotonin and other Substances by GangliosideJournal of General Microbiology, 1963
- Tissue lipids as ion exchangers for cations and the relationship to physiological processesBiochimica et Biophysica Acta, 1962
- Serotonin receptors III. The role of salt formationBiochimica et Biophysica Acta, 1961
- THE QUANTITATIVE SEPARATION AND ESTIMATION OF GLYCOSPHINGOSIDES IN NERVOUS TISSUE, WITH ESPECIAL REFERENCE TO GANGLIOSIDESJournal of Neurochemistry, 1961
- Immunochemical studies of organ and tumor lipidsArchives of Biochemistry and Biophysics, 1961
- Über ein chromatographisch einheitliches hexosaminhaltiges Gangliosid aus MenschengehirnHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1961
- SEROTONIN RECEPTORS. I. EXTRACTION AND ASSAY OF A SUBSTANCE WHICH RENDERS SEROTONIN FAT-SOLUBLEProceedings of the National Academy of Sciences, 1958