Effects of 3,5-Dimethylisoxazole (U-21221) on Fat Metabolism

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Abstract
Summary 3,5-Dimethylisoxazole was shown to decrease FFA, increase specific activity of plasma FFA after injection of labeled pal-mitate but to have no effect on palmitate oxidation. These observations were interpreted to mean that U-21221 lowered FFA as a result of decreased release from depots. Depression of FFA occurred prior to the fall in blood sugar in intact rats treated with U-21221. The isoxazole caused a depression of FFA in barbiturate-treated intact rats and in eviscerated rats without producing depression of blood sugar. These results were interpreted to mean that either the effects of U-21221 on FFA and blood sugar were independent of each other or that barbiturates and evisceration can specifically block action of U-21221 on blood sugar.