Molecular Characterization of Ofloxacin-ResistantMycobacterium tuberculosisStrains from Russia

Abstract
In this work, we studied the variation in thegyrAandgyrBgenes in ofloxacin- and multidrug-resistantMycobacterium tuberculosisstrains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread of fluoroquinolone-resistant tuberculosis in Russia may be due, at least partly, to the prevalence of the Beijing genotype in a local population ofM. tuberculosis.

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