INHIBITION OF HUMAN GRANULOSA CELL PROGESTERONE SECRETION BY A GONADOTROPIN-RELEASING HORMONE AGONIST
- 1 May 1982
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 54 (5) , 1078-1080
- https://doi.org/10.1210/jcem-54-5-1078
Abstract
A gonadotropin-releasing hormone (Gn-RH) agonist was found to inhibit the secretion of progesterone by cultured human granulosa cells in a dose-dependent manner. Significant inhibition was observed at agonist concentrations of 10-9M. A Gn-RH antagonist had no marked effect upon progestin secretion, but it prevented the inhibitory effects of the Gn-RH agonist. We conclude that Gn-RH-like substances can directly affect human granulosa cell function.Keywords
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