An Eruptive Fever Involving the Skin and Mucous Membranes (Stevens–Johnson Disease)

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Abstract
IN 1866 von Hebra1 first described erythema multiforme as a generalized skin eruption without marked systemic symptoms; a rare type with fever, malaise, prostration and an accompanying severe stomatitis and purulent conjunctivitis was mentioned. Kaposi,2 in 1893, described an infrequent form with involvement of the mucous membranes. More recently, reports of erythema multiforme with occasional involvement of the mucous membranes of the eyes, mouth and genitalia have been presented.3 4 5 6 7 8 In 1922 Stevens and Johnson9 reported 2 cases of "a new eruptive fever associated with stomatitis and ophthalmia." They believed that the features of their cases, although previously described as a . . .