Iopamidol and meglumine diatrizoate: comparison of effects on patient discomfort during aortofemoral arteriography.

Abstract
Iopamidol was compared with Renografin-60 (meglumine diatrizoate) in a controlled, randomized double-blind study of 40 patients undergoing peripheral arteriography for arteriosclerotic occlusive disease to determine which agent caused less discomfort. Each patient was evaluated for objective signs of discomfort and subjective feelings of pain and heat. Monitoring was achieved by multiple physical examinations, chemical tests, ECG and intraarterial pressure recordings. Evidently iopamidol is safe and causes significantly less patient discomfort than Renografin-60.