SOME FACTORS WHICH INFLUENCE THE INHIBITION OF WATER LOSS IN ALBINO RATS BY PITUITRIN

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Abstract
When water was administered by mouth to albino rats and loss of body water measured as changes in body wt. with and without pituitrin, the following factors affected the reaction. Small rats lost water more rapidly than large rats and pituitrin was less effective in preventing or inhibiting wt. loss. Extremes of environmental temp., either cold or hot, depressed the water-retaining effect of pituitrin. Pituitrin retained water more effectively in rats dehydrated and thirsted for a prolonged period. Administered salt decreased the water-retaining effect of pituitrin and may reverse it. Factors which were found to have little or no effect on the reaction of albino rats to pituitrin included season, environmental light, air velocity and relative humidity.