Chiral differentiation in the deacylation of 6A-O-{2-[4-(2-methylpropyl)phenyl]propanoyl}-β-cyclodextrin
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 11,p. 759-760
- https://doi.org/10.1039/c39910000759
Abstract
In 0.1 mol dm–3 sodium carbonate buffer at pH 11.5 the pseudo first-order rate constants for the hydrolysis of the diastereoisomers of the title compound to give Ibuprofen {2-[4-(2-methylpropyl)phenyl]propanoic acid} and β-cyclodextrin are 2.97 × 10–5 s–1 and 3.16 × 10–4 s–1, with the diastereoisomer derived from (R)-Ibuprofen being the most susceptible to hydrolysis.Keywords
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